Good post from Fred Wilson, in turn quoting another good post from Vibhu Norby, debating the pros/cons of targeting mobile first. Much of the same debate I hear game devs having as of late, and so it's relevant to that crowd.
"I use my phone more than anything else. I just don’t think that an entrepreneur who wants a real shot at success should start their business there. The Android and iOS platform set us up to fail by attracting us with the veneer of users, but in reality you are going to fight harder for them than is worthwhile to your business. You certainly need a mobile app to serve your customers and compete, but it should only be part of your strategy and not the whole thing"